Metabolic diseases, including diabetes, obesity, and non-alcoholic fatty liver disease are reaching epidemic levels worldwide. Improper cellular energy production, storage, and use underlie many of these conditions.
A link has been recognized between iron overload and metabolic syndrome (MetS), a health disorder that greatly increases the risk of many chronic illnesses such as diabetes and heart disease.
Humans have enormous demands for blood production. Alterations in the functioning of the human blood system lie at the heart of many diseases, including cancer, infections, and auto-immune disorders.
The human intestine routinely encounters threatening bacteria that cause disease and death. These bacteria use strategies known as virulence mechanisms to infect and interfere with the normal function of cells, leading to disease.
Type 2 diabetes is a metabolic disease characterized by elevated circulating sugar levels that result from reduced insulin secretion from pancreatic beta cells and reduced sensitivity to insulin.
Obesity, type 2 diabetes, and cardiovascular disease share common features, including inflammation in multiple tissues.