Joint Canada-Israel Health Research Program
The Joint Canada-Israel Health Research Program (JCIHRP) is a seven-year, CAD 35 million partnership between the International Development Research Centre (IDRC), the Azrieli Foundation, the Canadian Institutes of Health Research (CIHR) and the Israel Science Foundation (ISF) that draws on the scientific strengths of Canadian and Israeli researchers in the broad field of biomedicine. The program will fund 30 collaborative projects involving researchers from Canada and Israel, as well as collaborators from low- and middle-income countries.
Projects to be funded through this year’s competition (Metabolism in health and disease) will add to the 24 joint projects selected through the first four calls for proposals:
- 1st call (2015) – Neuroscience
- 2nd call (2016) – Immunology
- 3rd call (2017) – Cancer
- 4th call (2018) – Neurobiology
- 5th call (2019) – Metabolism (see below list of funded projects)
The burden of neurological disorders has increased substantially over the past 25 years. For example, the expanded list of neurological conditions makes them the leading cause group of disability and the second-leading cause group of mortality worldwide. Furthermore, ongoing demographic changes in low and middle-income countries, such as lower child mortality rates and increases in aging populations, mean that the global number of patients needing neurological care will continue to grow. As such, additional research is critical to advancing our knowledge of the basic neurological mechanisms underlying neurological disorders. It is only with this evidence that we can design adequate services and therapeutic interventions.
The call for research proposals in the field of neurobiology was launched In October 2017. The proposals were evaluated by an international committee of 14 experts from eight countries, chaired by Professor Joshua Sanes from the Center for Brain Science at Harvard University. Six world-class teams were selected from among 45 proposals and will receive funding totaling up to CA$7 million over the next three years.
The following list of selected projects is in alphabetical order according to the Canadian nominated principal investigator's surname.
Molecular and structural mechanisms of astrocyte-mediated cognitive enhancement
Researchers: Dr Keith Murai (McGill University, Canada); Dr Inbal Goshen (Hebrew University of Jerusalem, Israel); Dr Shu-min Duan (Zhejiang University, China); Dr Marcelo Chacon and Dr Yorka Munoz (Universidad de Chile)
Restoration of visual function via perceptual learning that targets specific brain areas
Researchers: Dr Christopher Pack (McGill University, Canada); Dr Ehud Zohary (Hebrew University of Jerusalem, Israel); Dr Sujaya Neupane, Dr Srijana Adhikary, and Dr Keepa Vaidya (Tilganga Institute of Ophthalmology, Nepal)
Selective real-time monitoring of diverse neuronal types in the brain
Researchers: Dr Adrien Peyrache (McGill University, Canada); Dr Eran Stark (Tel-Aviv University, Israel); Dr Mariano Belluscio and Dr Daniela Piña Novo (Universidad de Buenos Aires, Argentina); Dr Hugo Merchant (Univerisidad National Autonoma de Mexico)
Deciphering the blueprint of healthy and diseased human brain through the generation of patterned cerebral organoids
Researchers: Dr Carol Schuurmans (Sunnybrook Research Institute, Canada); Dr Orly Reiner (Weizmann Institute of Science, Israel); Dr Shubah Tole (Tata Institute of Fundamental Research, India)
Synaptic mechanisms underlying perceptual learning
Researchers: Dr Melanie Woodin (University of Toronto, Canada); Dr Adi Mizrahi (Hebrew University of Jerusalem, Israel); Dr Antonia Marin-Burgin (Instituto de Investigación en Biomedicina, Argentina)
Functional connectomics of peripheral and central pain circuits
Researchers: Dr Gerald Zamponi (University of Calgary, Canada); Dr Alexander Binshtok (Hebrew University of Jerusalem, Israel); Dr Juliana Chichorro and Dr Erika Araya (Universidade Federal Do Parana, Brazil)
The JCIHRP call for research proposals in the field of metabolism in health and disease was launched In November 2018. The proposals were evaluated by an international committee of 15 experts from 9 countries, chaired by Dr. Alvin C. Powers from the Vanderbilt University Medical Center. Six world-class teams were selected from among 44 proposals and will receive funding totaling up to CAD 7 million over the next three years.
The following list of selected projects is in alphabetical order according to the Canadian Nominated Principal Investigator’s surname.
Microbiome mediation of intestinal pathogen virulence through dietary aromatic compound metabolism
Researchers: Marie Claire Arrieta Mendez (University of Calgary, Canada), Neta Sal-Man (Universitat Ben Gurion of the Negev, Israel), Luis Caetano Martha Antunes (Fundacao Oswaldo Cruz, Brazil)
G protein functional selectivity in metabolic disorders
Researchers: Michel Bouvier (Université de Montréal, Canada), Mickey Kosloff (University of Haifa, Israel), Claudio Costa-Neto (Universidade de Sao Paulo, Brazil)
Transcription factor interplay as a driving force in the hepatic response to fasting and its dysregulation in metabolic disease
Researchers: Carolyn Cummins (University of Toronto, Canada), Ido Goldstein (Hebrew University of Jerusalem, Israel), Luiz Romeiro (University of Brasilia, Brazil)
Metabolic and chromatin reprogramming of HSC during day-night oscillations and aging
Researchers: John Dick (University of Toronto, Canada), Tsvee Lapidot (Weizmann Institute of Science, Israel), Regina Markus (Universidade de Sao Paulo, Brazil)
Immunometabolic roles and therapeutic potential of glucose-dependent insulinotropic polypeptide (GIP)
Researchers: Daniel Drucker (Lunenfeld-Tanenbaum Research Institute, Canada), Chen Varol (Sourasky Medical Center, Tel-Aviv, Israel), Jean-Claude Mbanya (Université de Yaoundé, Cameroon), Amelio F. Godoy-Matos (Pontificia Universidade Catolica do Rio de Janeiro, Brazil),Bruno Geloneze (UNICAMP, Brazil), Joao Eduardo Salles (Santa Casa Medical School, Brazil), Sergio Zuniga-Guajardo (Universidad Autonoma de Nuevo Leon, Mexico), Pablo Aschner (Universidad Javeriana, Colombia), Juan Jose Gagliardino (Universidad Nacional De La Plata, Argentina)
The role of iron homeostasis in the microbiome mediated modulation of metabolic syndrome
Researchers: Gary Sweeney (York University, Canada), Esther Meyron-Holtz (Technion Faculty of Medicine, Israel), Brian Lee, Nisa Makruasi and Sivaporn Wannaiampikul (Srinakharinwirot University, Thailand)